Ebook BookPhosphoinositides II The Diverse Biological Functions (Subcellular Biochemistry)

[Download.KWv8] Phosphoinositides II The Diverse Biological Functions (Subcellular Biochemistry)

[Download.KWv8] Phosphoinositides II The Diverse Biological Functions (Subcellular Biochemistry)

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Book Details :
Published on: 2012-02-29
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Original language: English

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. Lipid - Wikipedia Bibliography. Bhagavan NV (2002). Medical Biochemistry. San Diego: Harcourt/Academic Press. ISBN 978-0-12-095440-7. Devlin TM (1997). Textbook of Biochemistry: With ... A Mosaic Activating Mutation in AKT1 Associated with the ... Original Article. A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome. Marjorie J. Lindhurst Ph.D. Julie C. Sapp Sc.M. Jamie K. Teer Ph.D ... Le Live Marseille : aller dans les plus grandes soires ... Retrouvez toutes les discothque Marseille et se retrouver dans les plus grandes soires en discothque Marseille. Autophagy in Human Health and Disease NEJM Review Article. Mechanisms of Disease. Autophagy in Human Health and Disease. Augustine M.K. Choi M.D. Stefan W. Ryter Ph.D. and Beth Levine M.D. Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... NanoTemper Technologies GmbH: Monolith NT.115 Series The Monolith NT.115 combines the versatility to use of a broad range of fluorophores and fluorescent proteins with all benefits of the MicroScale Thermophoresis ... 2016 Poster Authors and Abstracts CSU Annual ... 2016 CSU Biotechnology Symposium Posters with Author Listings and Abstracts. Poster : 1 Project Title: Modeling vascular endothelial cells to investigate repair of ... Ontogeny Anatomy Metabolism and Physiology of the ... ABSTRACT. This chapter presents an analysis and a summarized synthesis of our present knowledge of the biology of the thyroid gland phylogeny ontogeny ...
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